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Killedar, Suresh G.
- Screening of Antimicrobial Potential and Phytoconsituents for Different Extracts of Memecylon umbellatum Burm Inflorescences
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Authors
Affiliations
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur (M.S.), IN
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur (M.S.), IN
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 4 (2011), Pagination: 114-118Abstract
The plant Memecylon umbellatum Burm is small tree or shrub with beautiful purple inflorescences. Various other parts of the plant were studied for different medicinal properties but no scientific data on inflorescence except the description about its beauty and photographs. Hence in the present work efforts have been made to investigate antimicrobial properties and phytochemical screening of the inflorescence.
Six different extracts with non polar and polar solvents were screened for antimicrobial activity by cylinder cup plate method using standard cultures (ATCC), MIC by serial broth dilution and phytochemical screening was made with different chemical reagents. Ethyl acetate and methanol extracts have shown better activities compare to other extracts and were found significant compare to control and standard at tested concentrations. MIC for ethyl acetate and methanol extract was found at 0.5mg for most of the test organisms compare to 3 and 6mg for other extracts. All other extracts have shown very weak activity as compare to standard even at higher concentrations. Most of the non polar extracts showed almost negligible anti fungal and very weak antibacterial activities. Different extracts showed presence of tannins, glycosides, triterpens and steroids as important constituents.
Keywords
Antimicrobial, Phytochemical Screening, Memecylon umbellatum, Cylinder Cup Plate Method.
- Application of Seed Polymer Extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol
Abstract Views :144 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
3 Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
3 Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 3 (2017), Pagination: 167-172Abstract
Natural polymers are preferred over synthetic polymers as they are nontoxic, facilely available at low cost, utilized in low concentration, and are naturally extracted to provide nutritional supplement. Fast dissolving tablets have received ever-increasing demand during the last decade. Aim of present study was to develop fast dissolving tablet of Carvedilol using seed polymer extracted from Benincasa hispida. Prepared tablets were evaluated for pre and post compression parameters. Results of compatibility study using FTIR and DSC showed that Carvedilol is compatible with extracted seed polymer. Pre-compression studies revealed good micromeritic properties of powder blend for direct compression. In-vitro dissolution study showed that, tablet containing seed polymer released 90.67% of drug within 60 min. Study concluded that, natural superdisintegrant extracted from Benincasa hispida can be efficaciously utilized in tablet formulations which exhibit faster drug dissolution and hence may increase bioavailability, thereby, availing in efficacious therapy with improved patient compliance.Keywords
Benincasa hispida, Seed Polymer, Natural Superdisintegrant, Fast Dissolving Tablet, Carvedilol.References
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